N-MET Blog

How Energy Affects Emotions

Posted on April 03, 2013 by Joel Pardee

When taken together, and ONLY when taken together, the proprietary ingredients in N-MET act as metabolic modulators  and significantly reduce emotional stress, which in turn releases energy (versus consuming energy). 

Stress fatigues because it depletes your body's ATP.  ATP is completely necessary for productive purposes (like thinking and working).

Reducing stress releases ATP for use by our tissues for their specific function. Energy to the brain makes it possible to focus and think. 

Energy to the muscles lets us work.

But there is more to the N-MET energy story. 

Generating calming neurotransmitters requires ATP energy as well as the starting materials tryptophan, glycine, glutamine, and trimethylglycine. 

You can't build a house without a foundation, and your body cannot produce the required neurotransmitters without sufficient ATP.

So, we must produce optimal amounts of ATP in our cells. N-MET insures the sustained production of optimum levels of ATP energy by supplying N-acetyl-carnitine, which is required for efficient conversion of fats into ATP. 

And by supplying the complex mixture of folic acid, Vitamin B12 and Trimethylglycine necessary to remove damaging homocysteine from the cell, we protect and optimize the cell's ability to make ATP.

Again, administration of individual, simple metabolites such as B-vitamins and folic acid is NOT SUFFICIENT to drive ATP energy production or the synthesis of calming neurotransmitters. 

Rather, it is the balanced action of all of the N-MET components together that results in the natural calm and sustained energy that comes from a balanced metabolism.

Finally, we must recognize that a repaired physiology brings with it a healthy psychology.

A calm mind + abundant energy = confidence. 

The self-confidence to blow past confusion and fear of the unknown to fulfill our respective destinies. N-MET works equally well for children of all ages above 2 years, and I count myself as an overgrown child. 

 

By Dr. Joel Pardee
©2012 Neural Essence LLC 

 

If you have any questions please leave a comment below.

Posted in energy, neurotransmitters, physiology, vitamins

Autism, the Amygdala & Sensory Overload

Posted on December 18, 2012 by Kenneth Prince

 The brain needs sufficient Serotonin and L-Glycine to shut down an overactive amygdala. People with low levels of brain Serotonin and Glycine are stuck in a perpetual state of anxiety, fear, and unrest...Otherwise known as Sensory Overload.

 

 

Location of the Amygdala in the Brain.  The tiny amygdala is located on top of the spinal cord. Nerve signals from the eyes, ears and skin are transmitted to the amygdala where they are analyzed for potential danger.  


 

 

 

In our brain fearful emotions are controlled by a tiny organ called the amygdala.  It is often referred to as the Anger Management Center.

Here, sensory inputs such a sights, sounds and touch are analyzed for their "danger quotient" and appropriate responses are mounted to escape any perceived danger. 

Unless the reasoning part of the brain instructs the amygdala that the sensation is not dangerous, the amygdala automatically triggers a "fight or flight" response. 

We have all experienced the effects of being startled and scared. It's an adrenalin rush. In an instant we are on high alert. We panic and are overpowered with an intense urge to fight or run. At the instant we perceive danger, we are thrust into a state of Acute Sensory Overload.

Posted in amygdala, autism

N-MET Diet Basics

Posted on October 17, 2012 by Joel Pardee

There are several dietary issues we need to be aware of in general, and especially while taking N-MET.  



First, no diet drinks that contain phenylalanine (look on the label).  

Phenylalanine blocks the production of serotonin in the brain, and therefore compromises the calming effects of N-MET. Specifically phenylalanine blocks the uptake of tryptophan into the brain. Consequently, the brain cannot make serotonin, a major calming neurotransmitter.

Sugar is a very important part of our daily nourishment. In younger children it is the most important food for a rapidly developing brain.  Sugar is the brain's food and therefore keeps us mentally balanced. To be sure, we can overdo it, but low sugar diets can cause hypoglycemia, a state of extreme agitation and panic.

No caffeine.  Caffeine is a powerful stimulant that causes nervous agitation, especially in sensory overloaded people. 

  
A well balanced and appropriate diet is important to maintain mental balance. If you have any questions for me please ask in the comments below. 



Dr. Joel Pardee


Posted in autism, diet

N-MET Basics: Part I, How Does N-MET Work?

Posted on September 07, 2012 by Joel Pardee

N-MET brings calm and focus by stimulating (enhancing) the production of calming neurotransmitters in the brain, and by removing destructive metabolites already present. 

The result is improved brain function that allows us to better control our emotions.

Most supplements taken orally (or by other means) do not contain components that make it past the blood brain barrier and into the brain

This is where N-MET is different.

The most famous calming neurotransmitter is Serotonin (the "feel good" hormone), but there are 2 others that are just as important: Glycine and GABA.
(note: there are many others that play a very important role in the synthesis of these neurotransmitters. More on this later).

Elevation of the neurotransmitters; Glycine, GABA, and Serotonin, as well as removal of the destructive metabolite homocystine all contribute in a different way to control runaway emotions.

How do these neurotransmitter work?

Naturally, it is necessary to know how these neurotransmitters work. Basically, they work by damping down sensory overloads. Take serotonin for instance:

1. An explosion happens = this is a sensory overload to our sense of hearing.

2. We feel Immediate stress (fright). Startle Reflexes respond to help us escape. Cover ears, duck for cover, yell to others, etc.

3. Brain quickly analyses the situation. Determines if there is danger to us.

4. If no danger, the brain triggers an inhibitory response from neurons that contain serotonin. These directly damp down the excited neurons in the brain and thereby relieve the stressful startle response. We become calm. We can focus and think of ways to address the effects of the explosion.

5. Here's the critical point. In order to relieve the stress and panic of the startle response, we must have sufficient quantities of serotonin circulating in our brains to damp down the excitation.
And each and every one of us has slightly different levels of circulating serotonin; calm people have a lot, nervous people have less. People who suffer from acute anxiety and sensory overload have the least.
We all know that one of the hallmarks of autistic behavior is to cover the ears and find a quiet dark place even in normal ranges of sound and light. They are experiencing sensory overload. They are stuck in the startle response mode, because they are not making enough serotonin to damp it down. The result is anger, frustration, an inability to concentrate, and emotional stress (and a number of other behaviors we have seen).

N-MET works by enhancing the production of serotonin in the brain, so that sufficient quantities are present to modulate and balance our reactions to stress. It brings the brain back into metabolic balance. Enhancement of serotonin reduces anxiety by producing a calm and accepting mood. It also induces sleep (more on how N-MET helps with sleep later).

The other neurotransmitters glycine and GABA work in a similar manner. Enhancement of glycine levels in brain and reduction of homocysteine significantly reduces fear, anger and aggression (which in men especially is a normal response to danger).

In the same way, elevation of GABA moderates uncontrolled muscular movements, such as self-stimulation, hand flapping, pacing, etc.

In Part II we'll go into more detail on GABA and Glycine. Stay tuned.

If you have any questions about N-MET please feel free to contact me directly. 

-Dr. Joel


 

Posted in neurotransmitters

When N-MET Relieves Sensory Overload

Posted on July 26, 2011 by Joel Pardee

Differences in behavior should be quite noticeable early on. Anger, panic attacks and general agitation are noticeably diminished within a day. General mental confusion and lack of focus take longer (a week or so). Improved sleep about the same.

As you see the beneficial effect, you may want to increase the dose from 2.5ml to 5 ml AM and PM, or not, if the starting dose is working well.  Always go for the Minimal Effective Dose.  Do not give N-MET within 2-3 hours of bedtime because it contains sustaining energy components that are needed to drive the metabolic synthesis of the calming neurotransmitters, serotonin, glycine and GABA.

The effects are not cumulative or additive, but do require steady use of N-MET. If you miss a dose, just continue with the same regimen.

My wife and I experienced exactly the same sensory overload behaviors with our son, and they were completely and quickly relieved after starting him on N-MET. 

Remember to be mindful of sufficient sugar in your diet to prevent hypoglycemia.  Sugar is highly beneficial because it is the brain's primary energy source, and with N-MET to calm, sugar will not result in hyperactivity (given within reason).


If you have any questions at all please feel free to contact me at my personal email address: DrJoel@n-met.com or simply visit the Contact Us page and fill out the form. It will be forwarded directly to my email.



Posted in autism, neurotransmitters, physiology, sensory overload

Heat, Autism, and Sensory Overload

Posted on July 26, 2011 by Joel Pardee

It sometimes goes unnoticed that HEAT is a major cause of SENSORY OVERLOAD as it relates to autism. 

As the temperature rises, body metabolism works harder to keep body core temperature cool.  This leads to both physical and emotional stress.  We become agitated, lethargic, frustrated and often downright angry.  

Those who are susceptible to SENSORY OVERLOAD feel doubly stressed and out of control.  The solution is to stay hydrated, keep cool (AC is a must), lower the lights, find a quiet spot, and keep metabolites replenished.  

We find that spacing a dose of N-MET out in 4-5 hour intervals works best. For instance, 2-3 ml every 4-5 hours for younger children, 4-6 ml every 4-5 hours for the older ones.  In this sweltering summer, we must be alert to the damaging effects of HEAT on our sensitive children.


Note:  N-MET is not recommended for children who are chronically hyperactive, or those currently taking SSRI or MAO antidepressants.

Posted in autism, metabolic reactions, physiology, sensory overload

Recent Questions About N-MET

Posted on July 21, 2011 by Kenneth Prince

Dr. Joel Pardee answers questions from N-MET users or prospective users. He can be reached at DrJoel@n-met.com. Or you can simply fill out the form at our Contact N-MET page and your question will be forwarded directly to Joel.




Q: I have a 7 year old daugther that has autsim...[we are] having problems with her getting upset and trying to bite herself or stomp her feet very hard, some times she gets out of control. [I] Would like to now more about the product. Looking forward to hearing from you thanks.

Dr. Joel's Answer: I believe your daughter is the perfect candidate for N-MET.  My wife and I experienced exactly the same Sensory Overload behaviors with our son, and they were completely and quickly relieved after starting him on N-MET.  As detailed in our website, N-MET contains only pure, natural metabolites that are used everyday by our body and brain.  It is non-allergenic, drug-free, and contains no herbal extracts.  I urge you to try it at your earliest convenience.  Start with a dosage of 2.5 ml in the morning and late afternoon. Dilute it into a sweet, non-dairy drink that your girl enjoys. 

N-MET is extremely tart because there are no sweeteners (neither sugar nor artificial sweeteners) in it.  Watch her behaviors.  You should see beneficial effects within a day or two of the first dose (no kidding).  As you see the beneficial effect, you may want to increase the dose to 5 ml AM and PM, or not if the starting dose is working well. 

Always go for the Minimal Effective Dose.  Do not give N-MET within 2-3 hours of bedtime because it contains sustaining energy components that are needed to drive the metabolic synthesis of the calming neurotransmitters, serotonin, glycine and GABA. 

More details on the mechanism of action and metabolic enhancement therapy are posted on the N-MET.com website.  Also be mindful of sufficient sugar in your daughter's diet to prevent hypoglycemia.  Sugar is highly beneficial because it is the brain's primary energy source, and with N-MET to calm, sugar will not result in hyperactivity (given within reason). All our best wishes, and keep us apprised of your girl's progress.  We are here to help.

 


 

Q: ...What is in this medication?...With my autisic son I have to be very carefull of his diet and regulate any other changes. So what is in this that can make me confident that it's safe?

Dr. Joel's Answer: Thank you for your inquiry and your rightful and careful concerns for your guy.  We were just as cautious when we began to introduce components of the formula to our son.  A complete list of N-MET components can be found on the Ordering page of the N-MET.com website, along with common allergens that are NOT in the formula. 
 

In general, N-MET contains only the components that are listed, and each component is in pure form (>99% pure).  All of the ingredients are natural metabolites that we take in through our diet, and are used every day by the body and brain. They enter normal metabolic pathways and if not used are excreted within 4-6 hours (the normal turnover rate for these metabolites).  There is no accumulation with repeated dosage, and so no overdosing can occur. 
(editor's note: N-MET is manufactured in the USA, you can have confidence that we use the highest quality ingredients and manufacturing processes.)

The secret to N-MET is that the metabolites in the formula have been carefully chosen to selectively enhance the metabolic pathways that produce the inhibitory neurotransmitters; serotonin, glycine & GABA essential for modulation of Sensory Overload.  The mechanisms of action are documented in more detail in the website under the various headings of "What is Sensory Overload?", "Defeating Sensory Overload", etc. N-MET has a very tart taste because we purposely do not include sugar, artificial sweeteners or preservatives.  So, it must be diluted into any sweet, non-dairy drink that your son enjoys. We have learned from our son that sugar is an essential in his diet because it is the brain's primary source of energy, and because low blood sugar results in hypoglycemia with all the very debilitating behaviors attendant upon it. 

I hope this helps, and if you have any further questions/concerns at all, please don't hesitate to Contact Me.  We are here to help. Best of Luck to you and yours.  It worked wonders for us. Here's confidently hoping it will for you.

 


 

Q: Hi, My son is autistic, 4 years old and recently put on Tenex to control aggression, impulsivity and self injurious behavior. I know Tenex affects norepinephrine and lowers blood pressure. So far he has calmed down but is more prone to crying. I worry about depression or long term side effects. Can your product work effectively as an adjunct to this medication?

Dr. Joel's Answer: Thank you for your thoughtful inquiry.  The short answer is YES, N-MET can counter the depressive effects of Tenex.  However, I am quite concerned over the depressive side effects of Tenex on a young child....(at the time of this publication)Tenex has not been FDA approved for ADHD/autism, and it has not been approved for children under the age of 12. It is an anti-hypertensive that lowers blood pressure and slows heart rate. The result is a general depression of body function, including brain function, hence the obvious clinical depression that your son is exhibiting.  Proceed with extreme caution with this drug.  In truth, I would take the agitation over depression. I would also monitor his vital signs daily (blood pressure, heart rate).  Is he experiencing constipation, sleeplessness, fatigue, dizziness, etc.). Is his pupil reflex normal (constriction of the eye pupil when shining a light on it)? 


Although N-MET can be safely taken with Tenex, it is quite possible that the drug will mask N-MET's beneficial effects.  Better to slowly withdraw the drug by lowering the dose over time, and then supplement him with N-MET. I personally believe that taking him off Tenex can only improve his mind and body health.  Best of Luck, and kindly keep me informed of progress with you little guy.

 


 

Q: Both my husband and I are in the medical field. We have a 22 year old son with autism. His episodes of rage are becoming more violent and all evidenced based medication appear to be ineffective....It is a leap of faith for two scientists to try this product, despite your remarkable credentials....We are close to despair at this point, but still cautious about buying a product over the Internet.


Dr. Joel's Answer: Thank you for your candid and informative inquiry.  Here is my equally candid reply.  You and yours are in exactly the same position as my wife and I were with our son, now 20 years old.  N-MET was the answer, which is precisely why we decided to offer it to the public at large. 

As with you, all drug and behavioral therapies failed for him.  With testosterone driven emergence into adolescence, his rages, panic attacks, and insomnia reached epidemic proportions, and with increasing size and strength, he was getting dangerous. I invented N-MET out of the same sense of desperation that you are experiencing.  N-MET worked wonders for our guy.  He is now a happy, loving young man who is gaining self-confidence and is interacting with others beautifully (See "Dan's Story") on our N-MET.com website.  There you will also find descriptions of Sensory Overload and the physiologic mechanisms employed by N-MET to modulate it.  

N-MET is safe. It is composed only of pure metabolites used every day by our body and brain.  I am not a business man or sales person.  I am a professor of medical science, a research scientist, writer, teacher, former dean, father and caretaker of an autistic child.  So I'm not good at self-promotion.  But I am compelled to recommend this formula that changed all of our lives for the better.  Try it.  Start with a lower dose (2.5 ml in the AM and PM) and observe.  You will then be in position to increase the dose as you see fit.  We do 5 ml at 4-5 hour intervals (the normal turnover rate for these metabolites).  

The effect of N-MET on quelling anger and agitation should be evident within an hour or two of taking the 1st dose (I'm not kidding). Do not take N-MET within 2-3 hours of bedtime, since it contains components to enhance the sustained production of ATP energy to drive the synthesis of the inhibitory neurotransmitters, serotonin, glycine and GABA. Every physiology is unique, so the effect will vary with individuals.  However, we have many, many success stories that convince us of the general applicability of N-MET to calm, focus and energize.... As for the drugs, I am dead set against them....It is not at all clear to me that [they are] beneficial for autism or ADHD.  My very best to your family and especially your guy.  There is a fine person waiting to be released into his true self.   Finally, Keep the Faith and let me know how you are progressing.

Posted in metabolic reactions, neurotransmitters, physiology, sensory overload

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